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  6. Aureobasidin A

Aureobasidin A

Aureobasidin A (AbA) is a cyclic depsipeptide antibiotic, isolated from the filamentous fungus Aureobasidium pullulans R106, which is toxic to yeast at low concentrations (0.1–0.5 μg/ml). Sensitive species include Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida glabrata, Aspergillus nidulans and A. niger. AbA inhibits a yeast enzyme, inositol phosphorylceramide (IPC) synthase, which is expressed from the AUR1 gene. Expression of a mutant gene, AUR1-C, in transformed yeast confers resistance to the drug.

Brand: Takara

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Product CodeProduct Product Description Price (Excl gst) Qty Add
CLT630466 Aureobasidin A, 1 mg Aureobasidin A, 1 mg Login for price  
CLT630499 Aureobasidin A,10 mg Aureobasidin A,10 mg Login for price  

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Overview

  • Stringent drug-selectable marker for yeast
  • Aureobasidin A resistance is an ideal reporter for yeast two-hybrid studies
  • Provides exceptional screening results with Matchmaker Gold Yeast One- and Two-Hybrid Systems

Applications

  • Yeast two-hybrid studies
  • Yeast one-hybrid studies

Properties

  • Molecular Weight 1,100 Da
  • Insoluble in water