Description
Interferon alpha-2 (IFN-α2) is a cytokine encoded by the IFNA2 gene located on chromosome 9. It belongs to the Type 1 IFN family which includes 13 α subtypes, 1 β, and 1 ω. IFN-α2 was the first of these subtypes to be produced pharmaceutically and is the most widely studied. The mature secreted protein consists of 165 amino acids with 5 α-helices and two disulfide bonds. There are a several allelic variants of IFN-α2, including IFN-α2a, IFN-α2b, and IFN-α2c. IFN-α2 can act on all cell types due to the ubiquitous expression of the Type 1 IFN receptor (IFNAR).
IFN-α2 acts to combat infection by stimulating the production of proteins that inhibit viral replication and prevent viral entry into neighboring cells. IFN-α2 can stimulate the immune system by initiating T and NK cell mediated cytotoxicity. IFN-α2 also can inhibit cancer cell proliferation and activate immune system to target cancer cells. IFN-α2 has been used therapeutically in a variety of viral infections (including hepatitis B and C) and certain cancers (such as melanoma, renal cell carcinoma).
BioLegend's LEGEND MAX™ Human IFN-α2 ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a monoclonal mouse anti-human IFN-α2 capture antibody. The detection antibody is a biotinylated monoclonal mouse anti-human IFN-α2 antibody. This kit is specifically designed for the accurate quantitation of human IFN-α2 from cell culture supernatant, serum, plasma and other biological fluids. Different IFN-α2 allelic variants can be detected equally. It is analytically validated with ready-to-use reagents.
For more information or documentation, please visit: https://www.biolegend.com/en-us/products/legend-max-human-ifn-alpha-2-elisa-kit-with-pre-coated-plate-16920
Kit Contents
- Anti-Human IFN-α2 Pre-coated 96-well Strip Microplate
- Human IFN-α2 Dectection Antibody
- Human IFN-α2 Standard
- Matrix A
- Avidin-HRP
- Assay Buffer G
- Wash Buffer (20X)
- Substrate Solution F
- Stop Solution
- Plate Sealers
Menu
X
