Applications
Mouse IL-5 can be used for a variety of applications including:
- Cultivation and differentiation of eosinophils.
- Investigation on allergies, parasitic infections, and tumors.
Background information
Interleukin 5 (IL-5), also known as eosinophil differentiation factor (EDF) or eosinophil colony stimulating factor (Eo-CSF), belongs to the hematopoietic family of cytokines, together with IL-3 and GM-CSF, whose receptors share the common-cytokine-receptor β-chain. IL-5 is secreted by T helper cells, mast cells, and eosinophils and mainly acts as a key hematopoietic growth factor for the proliferation and activation of eosinophils, but also promotes the secretion of immunoglobulins by B cells, and the generation of cytotoxic T cells. Through the activation of eosinophils, IL-5 mediates several allergic diseases, but it is also involved in parasitic infections and tumor development.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Biological activity
Proliferation of human TF-1 cells
research grade: ≥ 5×105 U/mg
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