MACS GMP Recombinant Human IL-2 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.
Disclaimer
MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications.
Background information
IL-2 is a typical four α-helix bundle cytokine and is produced by activated T cells, especially the CD4+ T helper cell population. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β-chain, and common γ-chain.
Applications
MACS GMP Recombinant Human IL-2 can be used for a variety of applications, including the ex vivo activation and expansion of T cells, e.g., antigen-specific cytotoxic T lymphocytes or regulatory T cells or the ex vivo stimulation of NK cells.
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
Biological activity
The specific activity is determined by proliferation assay according to Gearing and Bird using CTLL-2 cells. The proliferation assay was calibrated with the 2nd international standard for human IL-2 (NIBSC code 86/500) provided by the National Institute for Biological Standards and Control.
Specific activity: ≥ 1×106 IU/mg
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