Clone REA327 recognizes the human CD240DCE antigens, multi-pass membrane proteins which are also known as blood group Rhesus (DCE) polypeptides. The Rhesus (Rh) blood group system is the most clinically significant blood group system after ABO. At present, the Rh blood group system consists of 50 defined blood-group antigens, among which the antigens D, C, and E are the most important. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic CD240D (RhD) protein on the surface of erythrocytes. Besides its role in blood transfusion, the Rh blood group system – specifically, the CD240D antigen – is used to determine the risk of hemolytic disease of the newborn as prevention is the best approach to the management of this condition.
Additional information: Clone REA327 displays negligible binding to Fc receptors.
Alternative names
RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)
Antigen: CD240DCE
Clone: REA327
Isotype: recombinant human IgG1
Isotype control: REA Control (S) antibodies
Alternative names of antigen: RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)
Entrez Gene ID: 6007, 6006
Molecular mass of antigen [kDa]: 45
Distribution of antigen: red blood cells
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
Storage: Store protected from light at 2–8 °C. Do not freeze.
Available conjugates: VioBright FITC, PE, APC, Biotin
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