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  5. CD209 (DC-SIGN)-FITC, human

CD209 (DC-SIGN)-FITC, human

MB130-092-873

For research use only. Size: for 100 tests. Clone DCN47.5 recognizes CD209 (Dendritic Cell Specific ICAM-3 Grabbing Non-integrin, DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, and on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14+ cells with a DC-like phenotype.

Brand: Miltenyi Biotec

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DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast.
HIV-1 uses this feature of DC-SIGN for efficient in -trans infection of CD4+ T cells.

Alternative names
CDSIGN, CLEC4L, DC-SIGN

Technical specifications
Antigen: CD209 (DC-SIGN)
Clone: DCN47.5
Isotype: mouse IgG1κ
Isotype control: Mouse IgG1 – isotype control antibodies
Alternative names of antigen: CDSIGN, CLEC4L, DC-SIGN
Entrez Gene ID: 30835
Molecular mass of antigen [kDa]: 46
Distribution of antigen: dendritic cells, endothelial cells, macrophages, skin, spleen
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
Storage: Store protected from light at 2–8 °C. Do not freeze.
Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, pure