Clone REA337 recognizes the human CD201 antigen, a single-pass type I membrane protein which is also known as endothelial protein C receptor (EPCR). CD201 is strongly expressed in the endothelial cells of arteries and veins in heart and lung, and less intensely in capillaries in the lung and skin. It is also expressed on a subset of neutrophils, monocytes, and several tumor cells. The major role of CD201 is anticoagulation. CD201 binds to protein C with high affinity and augments the activation of protein C by the thrombin-thrombomodulin complex. Another important functional aspect of CD201 is its role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Mutations in the CD201 gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
Additional information: Clone REA337 displays negligible binding to Fc receptors.
Alternative names
Procr, CCCA, CCD41, EPCR
Antigen: CD201 (EPCR)
Clone: REA337
Isotype: recombinant human IgG1
Isotype control: REA Control (S) antibodies
Alternative names of antigen: Procr, CCCA, CCD41, EPCR
Entrez Gene ID: 10544
Molecular mass of antigen [kDa]: 25
Distribution of antigen: endothelial cells, heart, lung, skin, leukocytes, monocytes, other
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
Storage: Store protected from light at 2–8 °C. Do not freeze.
Available conjugates: FITC, PE, PE-Vio770, APC-Vio770, Biotin
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