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  5. CD117 MicroBeads, mouse

CD117 MicroBeads, mouse

MB130-091-224

CD117 MicroBeads have been developed for the positive selection of hematopoietic stem and progenitor cells from mouse bone marrow . In addition, CD117 MicroBeads have been successfully used for the isolation of a variety of tissue stem cells, e.g. differentiated embryonic stem cell cultures, or amniotic fluid-derived stem cells. For research use only. Size: for 1×10^9 total cells

Brand: Miltenyi Biotec

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Background information
CD117 (c-kit) is a receptor tyrosine kinase expressed on the majority of hematopoietic stem and progenitor cells, on some tissue stem cells as well as mature mast cells. Stimulation of CD117 by its ligand, the cytokine stem cell factor (SCF), is important for stem cell survival and maintance.
Downstream applications
Further flow cytometric analysis or sorting of isolated CD117+ cells, e.g. into LSK populations.
Transplantation of CD117+ bone marrow cells, e.g. after myocardial infarction for differentiation into smooth muscle cells, myocytes, and endothelial cells.
Columns
MS, LS, XS, or autoMACS® Columns.