NG2/AN2+ glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2+ cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2+ glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2.
Alternative names
CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Technical specifications
Antigen: AN2
Clone: 1E6.4
Isotype: rat IgG1
Isotype control: Rat IgG1 – isotype control antibodies
Alternative names of antigen: CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Entrez Gene ID: 1464
Molecular mass of antigen [kDa]: 248
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
Storage: Store protected from light at 2–8 °C. Do not freeze.
Available conjugates: PE, Biotin, pure
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